Tetrahydroxystilbene-2-O-β-D-glucoside-product

Description	Tetrahydroxystilbene-2-O-β-D-glucoside (EH-201) is a low MW inducer of erythropoietin. Tetrahydroxystilbene-2-O-β-D-glucoside induces expression of erythropoietin, PPAR-γ coactivator 1α (PGC-1α) and haemoglobin in astrocytes and PC12 neuronal-like cells. In vivo, Tetrahydroxystilbene-2-O-β-D-glucoside treatment restores memory impairment, as assessed by the passive avoidance test, in SD, Aβ and KA mouse models. In the hippocampus of mice given Tetrahydroxystilbene-2-O-β-D-glucoside in their diet, levels of erythropoietin, PGC-1α and haemoglobin were increased. Treatment with Tetrahydroxystilbene-2-O-β-D-glucoside might be a therapeutic strategy for memory impairment in neurodegenerative disease, physiological ageing or traumatic brain injury.
Synonyms	tetrahydroxyl diphenylethylene-2-o-gluco, 何首乌苷, EH-201
molecular weight	406.38
Molecular formula	C20H22O9
CAS	55327-45-2
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year
Solubility	DMSO: 60 mg/mL (147.65 mM)
References	1. Activating mitochondrial function and haemoglobin expression with EH‐201, an inducer of erythropoietin in neuronal cells, reverses memory impairment[J]. British Journal of Pharmacology, 2015, 172(19):4741-4756.

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