Description | Tetrahydropapaverine hydrochloride (Norlaudanosine HCl) , an analogue of salsolinol and tetrahydropapaveroline, has neurotoxicity on dopamine neurons. |
In vivo | 在产生血清素的小鼠肥大细胞瘤P815细胞中,Tetrahydropapaverine可抑制血清素生物合成(IC50:7.5 μM),并降低色氨酸羟化酶活性(IC50:5.7 μM)。 |
Target activity | TPH:5.7 μM |
Synonyms | Tetrahydropapaverine HCl, Norlaudanosine HCl, Tetrahydroalkali hydrochloride, 四氢罂粟碱盐酸盐 |
molecular weight | 379.878 |
Molecular formula | C20H26ClNO4 |
CAS | 6429-04-5 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
Solubility | DMSO: 60 mg/mL (157.94 mM) |
References | 1. Kim EI, et al. Life Sci, 2004, 75(16), 1949-1957. 2. Goto K, et al. Brain Res, 1997, 54(1-2), 260-268. |