| Description | Substance P (Neurokinin P) (SP) is an undecapeptide (a peptide composed of a chain of 11 amino acid residues) member of the tachykinin neuropeptide family. |
| In vitro | Substance P（SP）通过神经激肽1受体（NK1-R）介导的脱敏和再敏感化过程，可能与NK1-R的内吞和循环有关。SP和NK1-R被共同内化进入相同的带有克拉斯林免疫反应的囊泡，随后被分配到不同的隔室中。SP在细胞表面和早期内体中保持完整，但在核周囊泡中缓慢降解。SP诱导NK1-R的克拉斯林依赖型内化。SP/NK1-R复合物在酸化内体中解离。SP被降解，而NK1-R循环到细胞表面。在转染的上皮细胞中，SP诱导NK1-R的内化[1]。 |
| Synonyms | Neurokinin P, P物质 |
| molecular weight | 1347.63 |
| Molecular formula | C63H98N18O13S |
| CAS | 33507-63-0 |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 10mM |
| References | 1. Grady EF, et al. Delineation of the endocytic pathway of substance P and its seven-transmembrane domain NK1 receptor. Mol Biol Cell. 1995 May;6(5):509-24. |