| Description | Scoulerine is an inhibitor of ß-site amyloid precursor protein cleaving enzyme 1(BACE1). Scoulerine a potent antimitotic compound that inhibits proliferation, arrests cell cycle, and induces apoptosis in cancer cells. |
| In vitro | 我们实验室分离出的四十六种异喹啉生物碱，涵盖了十一种结构类型，已对两种癌细胞系（Caco-2和Hep-G2癌细胞）以及正常人肺成纤维细胞进行了细胞毒性评估。仅有Scoulerine、aromoline、berbamine和parfumidine展现出显著的细胞毒性效果，但只有Scoulerine对Caco-2和Hep-G2细胞（IC50值分别为6.44 ± 0.87和4.57 ± 0.42）均有效。遗憾的是，除了parfumidine外，其他活性生物碱对正常人肺成纤维细胞也表现出细胞毒性[1]。 |
| molecular weight | 327.37 |
| Molecular formula | C19H21NO4 |
| CAS | 6451-73-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Chlebek J, et al. Cytotoxicity of Naturally Occurring Isoquinoline Alkaloids of Different Structural Types. Nat Prod Commun. 2016 Jun;11(6):753-6. 2. Habartova K, et al. Scoulerine affects microtubule structure, inhibits proliferation, arrests cell cycle and thus culminates in the apoptotic death of cancer cells. Sci Rep. 2018;8(1):4829. Published 2018 Mar 19. |