| Description | Glaucine has antitussive, antioxidative potential and antiviral activities, it may be an anti-arthritic agent, it can enhance LPS and zymosan-induced IL-10 production. Glaucine can inhibit the migration and invasion of human breast cancer cells by MMP-9 inhibitory activity, attenuating IκBα and NF-κB activities. |
| Target activity | PDE4:3.4 µM (Ki) |
| molecular weight | 355.43 |
| Molecular formula | C21H25NO4 |
| CAS | 475-81-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 30mg/ml(84.41mM) |
| References | 1. Meyer G M J , Meyer M R , Wink C S D , et al. Studies on the in vivo contribution of human cytochrome P450s to the hepatic metabolism of glaucine, a new drug of abuse[J]. Biochemical Pharmacology, 2013, 86(10):1497-1506. 2. Spasova M , Philipov S , Nikolaeva-Glomb L , et al. Cinnamoyl- and hydroxycinnamoyl amides of glaucine and their antioxidative and antiviral activities[J]. Bioorganic & Medicinal Chemistry, 2008, 16(15):7457-7461. 3. Gyurkovska V , Philipov S , Kostova N , et al. Acetylated derivative of glaucine inhibits joint inflammation in collagenase-induced arthritis[J]. Immunopharmacology & Immunotoxicology, 2014, 37(1):1-7. |