| Description | Safranal is the special volatile aroma compound of saffron.Safranal has neuroprotective and anti-inflammatory effects and has the potential for Parkinson’s disease research. |
| In vitro | 首先，评估了safranal对OLN-93细胞活力的潜在毒性效应。此外，细胞预先用safranal（0.1、1、10、50、100和200 μM）处理2小时，随后暴露于谷氨酸（16 mM）或喹啉酸（8 mM）的毒性作用24小时，采用相同的处理方法。结果显示：在1-800 μM浓度范围内，safranal对细胞活力没有毒性影响（p>0.05）。在超过1 μM浓度下对细胞进行safranal处理后，细胞活力在经受谷氨酸或喹啉酸损伤后显著提高（p<0.01）。safranal的细胞保护潜力还伴随着ROS积累（p<0.001）和丙二醛水平（p<0.001）的减少，这些都是经过谷氨酸或喹啉酸损伤后的结果。数据表明，safranal通过抑制氧化应激参数，展现出对寡突胶质细胞的保护潜力。 |
| In vivo | Safranal（200-500 mg/kg；口服；持续7天）轻微恢复了结肠长度和体重百分比的损失，并显著降低了DAI评分[2]。 |
| Synonyms | 2,3-二氢-2,2,6-三甲基苯甲醛, 藏红花醛, 藏红花 |
| molecular weight | 150.22 |
| Molecular formula | C10H14O |
| CAS | 116-26-7 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 100 mg/mL (665.69 mM), Sonication is recommended. Ethanol: 100 mg/mL (665.69 mM）, Sonication is recommended. |
| References | 1. Safranal Attenuates Excitotoxin-Induced Oxidative OLN-93 Cells Injury 2. Peeraphong Lertnimitphun, et al. Safranal Alleviates Dextran Sulfate Sodium-Induced Colitis and Suppresses Macrophage-Mediated Inflammation. Front Pharmacol. 2019 Nov 1;10:1281. |