| Description | Rhein (NSC 38629) is an anthraquinone compound extracted from Polygonaceae Rheum Officinale with anti-inflammation and antitumor activities. |
| In vitro | 在患有糖尿病肾病的db/db小鼠体内,Rhein通过降低血浆中的胆固醇（Chol）,甘油三酯（TG）,低密度脂蛋白胆固醇（LDL-C）和ApoE和肾组织中转化生长因子-β1（TGF-β1）,能够有效改善糖尿病肾脏病变和减轻高脂血症. |
| In vivo | 在软骨细胞中,Rhein（35 μM）通过减少IL-1R的数量和抑制IL-1β诱导的NO产生,能够有效抑制人骨关节炎滑膜中IL-1β的合成,以及在软骨中产生作用。在早幼粒细胞白血病细胞（HL-60）中,Rhein 能够诱导细胞凋亡。 |
| Synonyms | Rheinic Acid, Monorhein, 大黄酸, NSC 38629, Rheic Acid, Rhubarb yellow |
| molecular weight | 284.22 |
| Molecular formula | C15H8O6 |
| CAS | 478-43-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 5.45 mg/mL (19.19 mM), Sonication is recommended. |
| References | 1. Martel-Pelletier J, et al. J Rheumatol, 1998, 25(4), 753-762. 2. Pelletier JP, et al. J Rheumatol, 1998, 25(12), 2417-2424. 3. Lin S, et al. Arch Biochem Biophys, 2003, 418(2), 99-107. 4. Gao Q, et al. Planta Med, 2010, 76(1), 27-33. 6. Hou ML, et al. The Drug-Drug Effects of Rhein on the Pharmacokinetics and Pharmacodynamics of Clozapine in Rat Brain Extracellular Fluid by In Vivo Microdialysis. J Pharmacol Exp Ther. 2015 Oct;355(1):125-34. 7. Yan-Xi Zhou, et al. Rhein: A Review of Pharmacological Activities. Evid Based Complement Alternat Med. 2015; 2015: 578107. |