| Description | Proxyphylline (7-(2-Hydroxypropyl)theophylline) is a dual of adenosine A1/A2a receptor inhibitor and phosphodiesterase (PDE) inhibitor. Proxyphylline acts as a cardiac stimulant, vasodilator and bronchodilator. |
| In vitro | Proxyphylline通过抑制气管PDE活性，在100 μg/mL浓度下可获得气管平滑肌的半最大松弛[1]。 |
| Synonyms | 羟丙茶碱, 7-(2-Hydroxypropyl)theophylline |
| molecular weight | 238.24 |
| Molecular formula | C10H14N4O3 |
| CAS | 603-00-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 47 mg/mL (197.28 mM) |
| References | 1. Kukovetz W R , G Pöch, Holzmann S . Overadditive synergism between theophylline, diprophylline and proxyphylline in tracheal smooth muscle relaxation[J]. Arzneimittel-Forschung, 1983, 33(10):1450-1454. 2. Takeda K , Katano Y , Nakagawa Y , et al. EFFECTS OF AMINOPHYLLINE, PROXYPHYLLINE AND A PROXYPHYLLINE-MELILOTUS EXTRACT-RUTIN MIXTURE (THEOESBERIVEN) ON THE HEART AND THE CORONARY CIRCULATION[J]. The Japanese Journal of Pharmacology, 1977, 27(5):709-720. 3. Rasmussen F V , Waldorff S , Madsen L . Pharmacokinetics and bronchodilatory effect of proxyphylline and theophylline.[J]. Eur J Respir Dis, 1984, 65(1):20-27. |