| Description | Oleoylethanolamide (N-Oleoylethanolamide) is a high affinity endogenous agonist of PPAR-α. |
| In vitro | 体外研究显示，OEA能够通过抑制Smad2/3的磷酸化、α-SMA表达，以及肌成纤维细胞转化，来抑制转化生长因子β1激活的HSCs。 |
| In vivo | OEA（每天5mg/kg体重，腹腔注射）的治疗显著抑制了两种实验动物模型中肝纤维化的进程，其机制为阻断肝星状细胞（HSCs）的激活。肝组织基因表达分析显示，OEA抑制了α-平滑肌肌动蛋白（α-SMA）和胶原基质的表达，这些均为纤维化标志物及涉及炎症和胞外基质重塑的相关基因。 |
| Synonyms | 油酰单乙醇胺, N-Oleoylethanolamide, Oleamide MEA, Oleic acid monoethanolamide |
| molecular weight | 325.53 |
| Molecular formula | C20H39NO2 |
| CAS | 111-58-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: < 0.1 mg/mL (insoluble) DMSO: 19.83 mg/mL (60.92 mM), Sonication is recommended. |
| References | 1. Chen L, et al. Oleoylethanolamide, an endogenous PPAR-α ligand, attenuates liver fibrosis targeting hepatic stellate cells. Oncotarget. 2015 Dec 15;6(40):42530-40 |