| Description | Propylparaben (Propyl parahydroxybenzoate) is an antimicrobial agent, preservative, flavouring agent |
| In vitro | Propylparaben(PPB) suppressed the epileptiform activity in registered neurons.?This effect disappeared when PPB was removed from the solution of incubation.?PPB exerts an antiepileptic effect on CA1 pyramidal neurons in vitro.?Therefore, PPB may represent an effective antiepileptic compound[1]. propylparaben disrupts antral follicle growth and steroidogenic function by altering the cell-cycle, apoptosis, and steroidogenesis pathways[1]. |
| Cell experiments | Experimental conditions were as follows: a) basal recordings during which artificial cerebrospinal fluid (ACSF) (in mM: NaCl,125; KCl, 3; Na2HPO4, 1.25; NaHCO3, 25; MgCl2, 2; CaCl2, 2-D-(+)-glucose, 10; gassed with a mixture of 95% O2–5% CO2) was perfused; b) ACSF plus Propylparaben(PPB) (500 μM); c) 4-AP (100 μM) in Mg2+free-ACSF; d) 4-AP in Mg2+free-ACSF plus vehicle (dimethyl sulfoxide, DMSO at 0.04%); e) 4-AP in Mg2+free-ACSF plus drugs (phenytoin (PHT), 200 μM; PPB, 200 and 7500 μM). Each experimental condition lasted for 10 min. The onset of 4-AP-induced epileptiform activity was considered when bursts of 5 of more consecutive action potentials (APs) were present. The number of APs and excitatory postsynaptic potentials (EPSPs) greater than 1 mV and less than 10 mV of amplitude were quantified during periods of 5 min for each experimental condition[2] |
| Synonyms | 羟苯丙酯, Propyl 4-hydroxybenzoate, 尼泊金丙酯, Propyl parahydroxybenzoate |
| molecular weight | 180.2 |
| Molecular formula | C10H12O3 |
| CAS | 94-13-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 60 mg/mL (332.96 mM) |
| References | 1. Gal A, Gedye K, Craig ZR, Ziv-Gal A.Propylparaben inhibits mouse cultured antral follicle growth, alters steroidogenesis, and upregulates levels of cell-cycle and apoptosis regulators[J].Reprod Toxicol. 2019 Jul 12;89:100-106. 2. Lara-Valderrábano, Leonardo, Galván, Emilio J, Rocha L . Propylparaben suppresses epileptiform activity in hippocampal CA1 pyramidal cells, in vitro[J]. Epilepsy Research, 2017, 136:126-129. |