| Description | Harmaline hydrochloride (Harmidine hydrochloride) is a fluorescent indole alkaloid from the group of harmala alkaloids and beta-carbolines. It is the partially hydrogenated form of harmine.Harmaline produces a generalized tremor in normal rats by inducing rhythmic firing of inferior olivary neurons |
| In vitro | Harmaline could up-regulate the expressions of cell cycle-related proteins of p-Cdc2, p21, p-p53, Cyclin B and down-regulate the expression of p-Cdc25C. In addition, Harmaline could up-regulate the expressions of Fas/FasL, activate Caspase-8 and Caspase-3[1]. |
| In vivo | Harmaline could exert on antitumor activity with a dose of 15?mg/kg/day in vivo, which is related with cell cycle arrest.Harmaline also induces cognitive disturbances such as motor and spatial learning impairments. Lower doses of harmaline (5–10 mg/kg) have anxiogenic effects since higher doses (20 mg/kg) have anxiolytic-like properties[1]. |
| Synonyms | Harmidine hydrochloride |
| molecular weight | 250.72 |
| Molecular formula | C13H15ClN2O |
| CAS | 363-11-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: 25.64 mg/mL (102.26 mM), Sonication is recommended. DMSO: 27.5 mg/mL (109.68 mM) |
| References | 1. Wang Y, Wang C, Jiang C, Zeng H, He X. Novel mechanism of harmaline on inducing G2/M cell cycle arrest and apoptosis by up-regulating Fas/FasL in SGC-7901 cells. Sci Rep. 2015;5:18613. Published 2015 Dec 18. doi:10.1038/srep18613 |