| Description | Primin is a natural product stored in trichomes on leaves and stems of Primula obconica, with antimycobacterial, and strong antineoplastic actions. |
| In vitro | Primin 对 Trypanosoma brucei rhodesiense (IC50 0.144 microM) 和 Leishmania donovani (IC50 0.711 microM) 显示出极高的活性，并且对哺乳动物细胞的细胞毒性较低 (IC50 15.4 microM)。针对 Mycobacterium tuberculosis、Trypanosoma cruzi 和 Plasmodium falciparum，Primin 只表现出中等的抑制活性。在采用 Trypanosoma b. brucei 啮齿动物模型进行的体内有效性测试中，通过腹膜注射给予 20 mg/kg 的 Primin 未能治愈感染。在用于 L. donovani 感染的小鼠上，Primin 在更高浓度下 (30 mg/kg, 通过 i.p. 路径注射) 在体内过于有毒。 |
| Target activity | Leishmania donovani:0.711 μM, T. brucei rhodesiense:0.144 μM |
| molecular weight | 208.25 |
| Molecular formula | C12H16O3 |
| CAS | 15121-94-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 60 mg/ml (288.12 mM) |
| References | 1. Tasdemir D, et al. Antituberculotic and antiprotozoal activities of primin, a natural benzoquinone: in vitro and in vivo studies. Chem Biodivers. 2006 Nov;3(11):1230-7. 2. Brondani DJ, et al. Synthesis and antitumour activity of the Primin (2-methoxy-6-n-pentyl-1,4-benzoquinone) and analogues. Med Chem. 2007 Jul;3(4):369-72. |