| Description | 6-Diazo-5-oxo-L-nor-Leucine (L-6-Diazo-5-oxonorleucine) is an antagonist of glutaminases (Ki : 6 μM). It is an antineoplastic antibiotic produced by an unidentified species of Streptomyces from Peruvian soil. |
| Target activity | Glutaminases:6 μM(Ki) |
| Synonyms | DON, L-6-Diazo-5-oxonorleucine, 6-重氮-5-氧代-L-正亮氨酸, Diazooxonorleucine |
| molecular weight | 171.15 |
| Molecular formula | C6H9N3O3 |
| CAS | 157-03-9 |
| Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 5 mg/ml （29.21 mM), Sonication is recommended. H2O: 12.5 mg/ml(73.03 mM), Sonication is recommended. |
| References | 1. Willis RC, et al. The inhibition by 6-diazo-5-oxo-l-norleucine of glutamine catabolism of the cultured human lymphoblast. J Cell Physiol. 1977 Dec;93(3):375-82. 2. Kulkarni RM, et al. Evaluation of genetic toxicity of 6-diazo-5-oxo-l-norleucine (DON). Toxicol Mech Methods. 2017 Sep;27(7):518-527. 3. Turley E A . The Control of Adrenocortical Cytodifferentiation by Extracellular Matrix***[J]. differentiation, 1980, 17(1-3):93-103. |