| Description | N-Methylcorydalmine may exhibit significant anti-hypoxia activity. |
| In vitro | METHODS AND RESULTS:To study the chemical constituents from the rhizome of Menispermum dauricum,fifteen compounds, N-Methylcorydalmine(1),thalifoline(2),stepholidine(3),acutumine(4),daurisoline(5),acutumidine(6),dauricicoline(7),bianfugecine(8),6-O-demethylmenisporphine(9),bianfugedine(10),dauricoside(11),eleutheroside D(12),aristolactone(13),aristoloterpenateⅠ?(14) and aristolochic acid(15) were isolated from 75% ethanol extract of Menispermi Rhizoma by using thin layer chromatography and column chromatography methods. Their structures were identified based on their physicochemical properties and spectral data. Among them,compounds 12-15 were obtained from the genus Menispermum for the first time. Six alkaloids with higher contents were subjected to evaluate the anti-hypoxic activities by using MTT method. CONCLUSIONS: As a result,six alkaloids exhibited significant anti-hypoxia activities. |
| molecular weight | 391.89 |
| Molecular formula | C21H26ClNO4 |
| CAS | 81010-29-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Chemical constituents from rhizome of Menispermum dauricum and their anti-hypoxic activities. Zhongguo Zhong Yao Za Zhi. 2019 Feb;44(4):723-729. |