| Description | Mogroside III-E is a cucurbitane-type compound isolated from Siraitia grosvenorii, has anti-inflammatory activity, it attenuates LPS-induced acute lung injury in mice partly through regulation of the TLR4/MAPK/NF-κB axis via AMPK activation. It also has anti-fibrotic activity, it reduces pulmonary fibrosis through Toll-Like receptor 4 pathways. |
| In vitro | MG IIIE提高了HG诱导的MPC-5细胞的活性，降低了炎症细胞因子的浓度，并减少了与氧化应激相关的标志物水平。此外，HG引起的足细胞凋亡在MG IIIE干预后被抑制，伴随着Bcl-2表达上调和Bax、cleaved caspase-3以及cleaved caspase-9表达下调。还发现MG IIIE能够激活AMPK/SIRT1信号通路，但是compound C抑制了此路径，并逆转了MG IIIE对HG刺激的足细胞中炎症、氧化应激和凋亡的抑制作用。 |
| Synonyms | 罗汉果皂苷ⅢE |
| molecular weight | 963.15 |
| Molecular formula | C48H82O19 |
| CAS | 88901-37-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 9.64 mg/mL (10 mM) |
| References | 1. Xue W , Mao J , Chen Q , et al. Mogroside IIIE Alleviates High Glucose-Induced Inflammation, Oxidative Stress and Apoptosis of Podocytes by the Activation of AMPK/SIRT1 Signaling Pathway[J]. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 2020, Volume 13:3821-3830. |