| Description | Lupenone is a natural product isolated from Rhizoma Musae and has good anti-diabetic activity,and has anti-inflammatory activity.lupenone were potent PTP1B inhibitors with IC50 values of 15.11±1.23μM. |
| In vivo | Lupenone significantly decreased acute and subacute inflammation in mice as well as the IL-1β and IFN-γ levels in the pancreas of diabetic rats[1]. |
| Target activity | PTP1B:15.11±1.23μM |
| molecular weight | 424.7 |
| Molecular formula | C30H48O |
| CAS | 1617-70-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: Slightly soluble |
| References | 1. Xu F , Yang L , Huang X , et al. Lupenone is a good anti-inflammatory compound based on the network pharmacology[J]. Mol Divers. 2. Seong S H , Roy A , Jung H A , et al. Protein tyrosine phosphatase 1B and α-glucosidase inhibitory activities of Pueraria lobata root and its constituents[J]. Journal of Ethnopharmacology, 2016:S0378874116311321. |