| Description | Rosmanol has antioxidant activity, it can activate the antioxidant response element. Rosmanol has biphasic modulation of GABAA receptors, demonstrates CNS activity in mouse models of antinociception, antidepressant and anxiolysis. Rosmanol potently induces apoptosis through both the mitochondrial apoptotic pathway and death receptor pathway in human colon adenocarcinoma COLO 205 cells. Rosmanol has anti-inflammatory activity, it potently inhibits lipopolysaccharide-induced iNOS and COX-2 expression through downregulating MAPK, NF-kappaB, STAT3 and C/EBP signaling pathways. |
| molecular weight | 346.42 |
| Molecular formula | C20H26O5 |
| CAS | 80225-53-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | Chloroform: Soluble DMSO: 60 mg/ml (173.2 mM) |
| References | 1. Abdelhalim A, et al. Antidepressant, Anxiolytic and Antinociceptive Activities of Constituents from Rosmarinus Officinalis [J]. J Pharm Pharm Sci. 2015;18(4):448-59. 2. Petiwala S M, Johnson J J. Diterpenes from rosemary (Rosmarinus officinalis): Defining their potential for anti-cancer activity[J]. Cancer Letters, 2015, 367(2):93-102. 3. Fischedick J T. Structure activity relationship of phenolic diterpenes from Salvia officinalis as activators of the antioxidant response element[J]. Bioorganic & Medicinal Chemistry, 2013, 21(9):2618-2622. |