| Description | 1. Linarin (Acacetin-7-O-rutinoside) (acacetin-7-O-β-d-rutinoside) shows selective dose dependent inhibitory effect on acetylcholinesterase. 2. Linarin alleviates GalN/LPS-induced liver injury by suppressing TNF-α-mediated apoptotic pathways. 3. Linarin prevents A beta-induced neurotoxicity through the activation of PI3K/Akt, which subsequently inhibits GSK-3b and up-regulates Bcl-2. 4. The piperine significantly enhanced the oral absorption of Linarin in rats by inhibiting P-glycoprotein mediated cellular efflux during the intestinal absorption and likely simultaneously by inhibiting the metabolism of Linarin. |
| Synonyms | Buddleoflavonoloside, Buddleoside, Acacetin-7-O-rutinoside, Acaciin, Linarine, 蒙花苷 |
| molecular weight | 592.55 |
| Molecular formula | C28H32O14 |
| CAS | 480-36-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | Pyridine, Methanol, etc.: Soluble DMSO: 91 mg/mL(153.6 mM) Ethanol: Soluble |
| References | 1. Kim S J , Cho H I , Kim S J , et al. Protective effect of linarin against d-galactosamine and lipopolysaccharide-induced fulminant hepatic failure[J]. European Journal of Pharmacology, 2014, 738:66-73. |