| Description | Alliin ((S)-3-(Allylsulphinyl)-L-alanine) is a garlic organosulfur compound that possesses various pharmacological properties.alliin protected against LPS-induced ALI by activating PPARγ, which subsequently inhibited LPS-induced NF-κB activation and inflammatory response. Alliin might be used as an anti-inflammatory agent in the treatment of ALI. |
| In vivo | LPS-induced ALI was induced in BALB/c mice by intranasal instillation of LPS.?Alliin was administered intraperitoneally to mice 1 h after LPS treatment.?Alliin markedly inhibited lung myeloperoxidase (MPO) activity and wet/dry (W/D) ratio induced by LPS.?Alliin also inhibited TNF-α and IL-1β in the bronchoalveolar lavage fluid (BALF) induced by LPS.?Furthermore, LPS-induced lung pathological injury was attenuated by treatment of alliin.?LPS-induced NF-κB activation was significantly inhibited by alliin.?In addition, the expression of peroxisome proliferator-activated receptor γ (PPARγ) was up-regulated by treatment of alliin.?Taken together,Alliin protected against LPS-induced ALI by activating PPARγ, which subsequently inhibited LPS-induced NF-κB activation and inflammatory response. |
| Synonyms | 蒜氨酸, (S)-3-(Allylsulphinyl)-L-alanine |
| molecular weight | 177.22 |
| Molecular formula | C6H11NO3S |
| CAS | 556-27-4 |
| Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 3 mg/mL (16.92 mM) |
| References | 1. Wang Y L , Guo X Y , He W , et al. Effects of alliin on LPS-induced acute lung injury by activating PPARγ[J]. Microbial Pathogenesis, 2017, 110:375-379. 2. Deng X, Yang P, Gao T, et al. Allicin attenuates myocardial apoptosis, inflammation and mitochondrial injury during hypoxia-reoxygenation: an in vitro study[J]. BMC Cardiovascular Disorders. 2021, 21(1): 1-9. |