| Description | Leptomerine is an alkaloid from stems of Esenbeckia leiocarpa Engl. (Rutaceae). Leptomerine shows as anticholinesterasic activity and can be used in Alzheimer Disease studies. |
| In vitro | 经生物活性引导的乙醇茎提取物分馏作业成功分离出六种生物碱：leiokinine A、Leptomerine、kokusaginine、skimmianine、maculine 和 flindersiamine。所有分离出的化合物均经过了乙酰胆碱酯酶抑制测试，在体外显示出了抗胆碱酯酶活性。其中生物碱 Leptomerine 表现出最高活性（IC50 = 2.5 mM），与参考化合物 galanthamine（IC50 = 1.7 mM）的活性相似。 |
| Target activity | AChE:2.5 mM |
| molecular weight | 201.26 |
| Molecular formula | C13H15NO |
| CAS | 22048-97-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 9 mg/mL (44.72 mM) |
| References | 1. Cardoso-Lopes EM, et al. Alkaloids from stems of Esenbeckia leiocarpa Engl. (Rutaceae) as potential treatment for Alzheimer disease. Molecules. 2010 Dec 13;15(12):9205-13. |