| Description | lavendustin A (RG-14355) is a potent, cell-permeable inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase. |
| Target activity | Tyrosine kinase:11 ng/mL |
| Synonyms | RG-14355, NSC 678027, 薰草菌素 |
| molecular weight | 381.38 |
| Molecular formula | C21H19NO6 |
| CAS | 125697-92-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 9.5 mg/mL(25 mM) |
| References | 1. Nam DH, et al. Synthesis and anticancer activity of chromone-based analogs of lavendustin A. Eur J Med Chem. 2010 Sep;45(9):4288-92 2. Löber K, et al. Influence of the tyrosine kinase inhibitors STI571 (Glivec), lavendustin A and genistein on human mast cell line (HMC-1(560)) activation. J Cell Biochem. 2008 Mar 1;103(4):1076-88 3. Lee KY, et al. Synthesis and anticancer activity of lavendustin A derivatives containing arylethenylchromone substituents. Eur J Med Chem. 2006 Aug;41(8):1991-6 |