| Description | Gigantol is a novel inhibitor of the Wnt/β-catenin pathway. It inhibits Wnt/β-catenin signaling through downregulation of phosphorylated LRP6 and cytosolic β-catenin in breast cancer cells. Gigantol may be developed as a promising neuroprotective agent for successful MSC transplantation in ischemic diseases, it shows the protective effect against hydrogen peroxide-induced apoptosis in rat bone marrow mesenchymal stem cells through the PI3K/Akt pathway.Gigantol inhibits aldose reductase gene to exert its anti-cataract activity. Gigantol induces growth inhibition and apoptosis of HepG2 cells via the PI3K/Akt/NF-κB signaling pathway.Gigantol also shows α-glucosidase inhibitory activity. |
| molecular weight | 274.31 |
| Molecular formula | C16H18O4 |
| CAS | 67884-30-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 45 mg/mL (164.05 mM) |
| References | 1. Yu S, et al. Gigantol inhibits Wnt/β-catenin signaling and exhibits anticancer activity in breast cancer cells:[J]. Bmc Complementary & Alternative Medicine, 2018, 18(1):59. 2. Chen H, et al. Protective effect of gigantol against hydrogen peroxide‑induced apoptosis in rat bone marrow mesenchymal stem cells through the PI3K/Akt pathway.[J]. Molecular Medicine Reports, 2018, 17(2):3267-3273. 3. Wu J, et al. Gigantol from Dendrobium chrysotoxum, Lindl. binds and inhibits aldose reductase gene to exert its anti-cataract activity: An in vitro, mechanistic study[J]. Journal of Ethnopharmacology, 2017, 198:255-261. 4. Chen H, et al. Gigantol attenuates the proliferation of human liver cancer HepG2 cells through the PI3K/Akt/NF-κB signaling pathway[J]. Oncology Reports, 2017, 37(2):865. |