| Description | Kansuinine A, a 95% ethanol extract from the roots of E. kansui, possesses an inhibitory effect on IL-6-induced Stat3 activation by activating ERK1/2. |
| In vitro | Kansuinine A 在0.78至12.50 microg/mL浓度范围内显著促进SPL增殖和PMphi产生NO[3]。 |
| molecular weight | 730.75 |
| Molecular formula | C37H46O15 |
| CAS | 57701-86-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: ≥ 100 mg/mL (136.85 mM) |
| References | 1. Stimulation of Nerve Growth Factor Production by Diterpenoids Isolated from Plants of Euphorbia Species. Bioscience, Biotechnology, and Biochemistry.1994 Aug 23:1749-1751. 2. Jong Sun Chang, et al. Kansuinine A and Kansuinine B from Euphorbia kansui L. inhibit IL-6-induced Stat3 activation. Planta Med. 2010 Oct;76(14):1544-9. 3. Xiaoyun Shu, et al. Bioassay-guided separation of the proinflammatory constituents from the roots of Euphorbia kansui. J Nat Med. 2010 Jan;64(1):98-103. |