Kaempferol 3-sophoroside-7-glucoside-product

Description	Kaempferol 3-sophoroside-7-glucoside is a bioactive ingredient in the Lei leaves, belonging to the flavonoid group, which has antioxidant and anti-obesity activities.
In vitro	The roasting process followed by a 30% EtOH extraction tended to enhance the content of kaempferol-3-sophoroside-7-glucoside. It effectively inhibited pancreatic lipase activity by 62.50 ± 4.81%, which was approximately 1.71 percentage points higher than that of the dried-nonroasted LCL extract (60.79 ± 3.75%). Its bioaccessible fraction obtained from in vitro digestion significantly and dose-dependently reduced intracellular lipid accumulation by adipocyte 3T3-L1 compared with a 30% EtOH extraction. At a concentration of 200 μg/mL, it inhibited lipid accumulation up to 29.55% in 3T3-L1 cells, which indicated that human digestive enzymes converted kaempferol-3-sophoroside-7-glucoside to kaempferol metabolites that have anti-obesity effects.[1]
In vivo	Apigenin 7-O-β-D-glucopyranoside and kaempferol-3-sophoroside-7-glucoside, among others, were the main chemical constituents of Pteris wallichiana J. Agardh extract (PEW). In LPS-induced Raw264.7 inflammation and DSS-induced mouse colon UC, PEW pretreatment can significantly reduce the expressions of inflammatory cytokines in vitro and in vivo. In DSS-induced UC mice, PWE can improve the abnormal pathological tissue damage by inhibiting oxidative stress and inflammation-related signaling pathways, and improve the intestinal barrier function.[1]
molecular weight	772.66
Molecular formula	C33H40O21
CAS	55136-76-0
Storage	store at low temperature,keep away from direct sunlight　\|　Powder: -20°C for 3 years \| In solvent: -80°C for 1 year
References	1. Choi EH, et al. Changes in the profiling of bioactive components with the roasting process in Lycium chinense leaves and the anti-obesity effect of its bioaccessible fractions. J Sci Food Agric. 2019;99(9):4482-4492. 2. Tao J, Huang Z, Wang Y, et al. Ethanolic Extract from Pteris wallichiana Alleviates DSS-Induced Intestinal Inflammation and Intestinal Barrier Dysfunction by Inhibiting the TLR4/NF-κB Pathway and Regulating Tight Junction Proteins. Molecules. 2022;27(10):3093.

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Kaempferol 3-sophoroside-7-glucoside

CAS No.: 55136-76-0