| Description | Jatrorrhizine (neprotin) is a protoberberine alkaloid isolated from Enantia chlorantha (Annonaceae) and other species. It was found to have antimicrobial and antifungal activity. It binds and noncompetitively inhibits monoamine oxidase (IC50 4 micromolar for MAO-A and 62 for MAO-B). |
| Target activity | MAO-A:4 μm, MAO-B:62μm |
| Synonyms | Yatrorizine, neprotin, 药根碱 |
| molecular weight | 338.38 |
| Molecular formula | C20H20NO4 |
| CAS | 3621-38-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble DMSO: 61 mg/mL(180.3 mM) |
| References | 1. Wu H1, He K2, Wang Y2, et al.The antihypercholesterolemic effect of jatrorrhizine isolated from Rhizoma Coptidis.Phytomedicine. 2014 Sep 25;21(11):1373-81. 2. Li J1, Li J, Jiao Y, Dong C.Spectroscopic analysis and molecular modeling on the interaction of jatrorrhizine with human serum albumin (HSA).Spectrochim Acta A Mol Biomol Spectrosc. 2014 Jan 24;118:48-54. 3. Mi R1, Hu YJ, Fan XY, Ouyang Y, Bai AM.Exploring the site-selective binding of jatrorrhizine to human serum albumin: spectroscopic and molecular modeling approaches.Spectrochim Acta A Mol Biomol Spectrosc. 2014 Jan 3;117:163-9. |