| Description | Anisodamine (6-beta-Hydroxyhyoscyamine) is an antagonist of muscarinic and nicotinic cholinoceptor with similar affinities at the muscarinic receptor as scopolamine and atropine. Anisodamine improve the microcirculation in states of shock and can be used in studies about organophosphate poisoning. |
| In vitro | 在RAW264.7细胞中，Anisodamine（100 μg/mL）阻断毒蕈碱受体，增加内源性ACh与α-7nAChR的结合，并减弱α-猪毒素的结合[3]。 |
| In vivo | 经腹腔给药，Anisodamine（50 mg/kg）显著降低了LPS诱导的休克小鼠的死亡率（20%）[3]。 |
| Synonyms | 6-Hydroxyhyoscyamine, 6-beta-Hydroxyhyoscyamine |
| molecular weight | 305.37 |
| Molecular formula | C17H23NO4 |
| CAS | 55869-99-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 90.0 mg/mL (294.7 mM) H2O: 18.0 mg/mL (58.9 mM), Sonication is recommended. |
| References | 1. Binding of tropane alkaloids to nicotinic and muscarinic acetylcholine receptors. Pharmazie. 1995 Jul;50(7):493-5. 2. Eisenkraft A, et al. Possible role for anisodamine in organophosphate poisoning. Br J Pharmacol. 2016 Jun;173(11):1719-27. 3. Liu C, et al. Antishock effect of anisodamine involves a novel pathway for activating alpha7 nicotinic acetylcholine receptor. Crit Care Med. 2009;37(2):634-641. |