| Description | Jamaicin (AnCoA4), an isoflavone derived from the chickweed plant, is an inhibitor of the STIM1-Orai1 channel that blocks calcium influx, reduces its interaction with STIM1, and inhibits T-cell activation. |
| Synonyms | An-Co-A4, AnCoA-4, An Co A4, AnCoA4 |
| molecular weight | 378.37 |
| Molecular formula | C22H18O6 |
| CAS | 24211-36-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Huong Doan Thi Mai, et al. Cytotoxic prenylated isoflavone and bipterocarpan from Millettia pachyloba. Planta Med. 2010 Oct;76(15):1739-42. 2. Sadaghiani AM, Lee SM, Odegaard JI, Leveson-Gower DB, McPherson OM, Novick P, Kim MR, Koehler AN, Negrin R, Dolmetsch RE, Park CY. Identification of Orai1 channel inhibitors by using minimal functional domains to screen small molecule microarrays. Chem Biol. 2014 Oct 23;21(10):1278-1292. doi: 10.1016/j.chembiol.2014.08.016. Epub 2014 Oct 9. PubMed PMID: 25308275. |