| Description | ISOBERGAPTEN is a plant growth regulating substance, it is the principal constituents responsible for the antimycobacterial activity of the roots of Heracleum maximum; it may form an important class of natural defensive agents against fungi. |
| In vitro | Isobergapten,(3R,8S)-Falcarindiol, bergapten, angelicin, sphondin, pimpinellin, isopimpinellin and 6-isopentenyloxyisobergapten were identified as the principal constituents responsible for the antimycobacterial activity of the roots of Heracleum maximum.??treatment for infectious diseases, specifically tuberculosis. |
| Cell experiments | A methanolic extract of Heracleum maximum roots was subjected to bioassay guided fractionation using the microplate resazurin assay (MRA) to assess inhibitory activity against Mycobacterium tuberculosis strain H37Ra. The antimycobacterial constituents were identified by NMR, MS and polarimetry. |
| molecular weight | 216.19 |
| Molecular formula | C12H8O4 |
| CAS | 482-48-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: < 2.16 mg/mL (10 mM, insoluble or slightly soluble) |
| References | 1. Neill T O , Johnson J A , Webster D , et al. The Canadian medicinal plant Heracleum maximum contains antimycobacterial diynes and furanocoumarins[J]. Journal of ethnopharmacology, 2013, 147(1):232-237. |