| Description | Isobarbaloin (Barbaloin-A) (Aloin) is a natural anthracycline from Aloe vera, is a tyrosinase inhibitor. |
| In vivo | 在MCF-7细胞系中,Aloin通过诱导细胞凋亡引起处于有丝分裂期的细胞比率减少,抑制拓扑IIα蛋白表达,并下调细胞周期B1蛋白的表达。HeLaS3细胞中,Aloin在生理浓度(IC50=97 μM)下表现出明显的抗增殖作用,导致细胞周期阻滞在S期,明显增加细胞凋亡。 |
| Synonyms | Aloin, Aloin-A, 芦荟甙, Barbaloin-A |
| molecular weight | 418.39 |
| Molecular formula | C21H22O9 |
| CAS | 5133-19-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 83 mg/mL (198.37 mM) H2O: 1 mg/mL (2.39 mM) Ethanol: 2 mg/mL (4.78 mM) |
| References | 1. Sun R , Zhai R , Ma C , et al. Combination of aloin and metformin enhances the antitumor effect by inhibiting the growth and invasion and inducing apoptosis and autophagy in hepatocellular carcinoma through PI3K/AKT/mTOR pathway[J]. Cancer Medicine, 2020, 9(3). |