| Description | Hentriacontane is a natural product with various pharmacological effects including anti-inflammatory, antitumor, and antimicrobial activities. |
| In vitro | Hentriacontane（10μM、5μM和1μM）在所有浓度下显著降低了研究中的所有炎症参数。研究了hentriacontane对NO、PGE2、LTB4以及LPS诱导的RAW 264.7细胞中NF-κB转移的抑制作用[2]。 |
| In vivo | Hentriacontane（5mg/kg、2mg/kg和1mg/kg）在所有浓度下也降低了研究中所有的炎症参数。在Balb/c小鼠中研究了对促炎症（TNF-α、IL-6、MCP-1和IL-1β）和抗炎症（IL-10）细胞因子的抑制[2]。 |
| molecular weight | 436.84 |
| Molecular formula | C31H64 |
| CAS | 630-04-6 |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: 1 mg/mL, Sonication is recommended. DMSO: Insoluble |
| References | 1. Kim SJ, et al. Antiinflammatory effect of Oldenlandia diffusa and its constituent, hentriacontane, through suppression of caspase-1 activation in mouse peritoneal macrophages. Phytother Res. 2011 Oct;25(10):1537-46. 2. Khajuria V, et al. Anti-inflammatory potential of hentriacontane in LPS stimulated RAW 264.7 cells and mice model. Biomed Pharmacother. 2017 Aug;92:175-186. |