| Description | AICAR phosphate (Acadesine phosphate) is an AMPK activator and inhibitor of autophagy, YAP, and mitophagy, as well as an adenosine analog that regulates glucose and lipid metabolism, and inhibits the production of pro-inflammatory cytokines and iNOS. |
| In vitro | HepG2 细胞分别用不同浓度的 AICAR phosphate（0.1-1.0 mM）处理 12、24 和 48 小时，最终结果显示 AICAR phosphate 降低了胰岛素受体蛋白的表达[1]。 |
| In vivo | 5 周龄的雄性 ZDF 大鼠被皮下注射一剂 AICAR phosphate（0.5 mg/g）或进行一次跑步训练，结果显示与未治疗的对照 ZDF 大鼠相比，运动组和接受 AICAR phosphate 注射的大鼠在白色腓肠肌中的 AMPK-α2 活性均显著增加[2]。 |
| Synonyms | AICA Riboside phosphate, Acadesine phosphate |
| molecular weight | N/A |
| Molecular formula | C9H14N4O5.xH3O4P |
| CAS | 681006-28-0 |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 75 mg/mL (210.54 mM) H2O: 80 mg/mL (224.57 mM), Sonication is recommended. |
| References | 1. Nakamaru K, et al. AICAR, an activator of AMP-activated protein kinase, down-regulates the IR expression in HepG2 cells. Biochem Biophys Res Commun. 2005 Mar 11;328(2):449-54 2. Pold R, et al. Long-term AICAR administration and exercise prevents diabetes in ZDF rats.Diabetes. 2005 Apr;54(4):928-34. 3. Drake JC, et al. AICAR treatment for 14 days normalizes obesity-induced dysregulation of TORC1 signaling and translational capacity in fasted skeletal muscle. Am J Physiol Regul Integr Comp Physiol. 2010 Dec;299(6):R1546-54. 4. Pold R, et al. Long-term AICAR administration and exercise prevents diabetes in ZDF rats.Diabetes. 2005 Apr;54(4):928-34. |