| Description | Gedunin is an important limonoid present in several genera of the Meliaceae family, mainly in seeds. Gedunin is an Hsp90 inhibitor, and inhibits ovarian cancer cell proliferation. |
| In vitro | Gedunin treatment is highly effective in inducing death of pancreatic cancer cells via intrinsic and extrinsic mediated apoptosis.?Gedunin inhibited metastasis of pancreatic cancer cells by decreasing their EMT, invasive, migratory and colony formation capabilities.?Gedunin treatment also inhibited sonic hedgehog signaling pathways.?Further, experiments with recombinant sonic hedgehog protein and Gli inhibitor (Gant-61) demonstrated that gedunin induces its anti-metastatic effect through inhibition of sonic hedgehog signaling.?The anti-cancer effect of gedunin was further validated using xenograft mouse model. |
| molecular weight | 482.57 |
| Molecular formula | C28H34O7 |
| CAS | 2753-30-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 60 mg/ml (124.33 mM) |
| References | 1. Subramani R , Gonzalez E , Nandy S B , et al. Gedunin inhibits pancreatic cancer by altering sonic hedgehog signaling pathway[J]. Oncotarget, 2016, 8(7). 2. Ah A , D E , Rh C , et al. Hsp90 inhibitor gedunin causes apoptosis in A549 lung cancer cells by disrupting Hsp90:Beclin-1:Bcl-2 interaction and downregulating autophagy[J]. Life Sciences, 2020, 256. |