| Description | Gastrodin (Gastrodine), an anti-inflammatory polyphenol, is extracted from Chinese natural herbal Gastrodia elata Blume. and benefits neurodegenerative diseases. |
| In vitro | 小鼠体内Gastrodin的LD50: >1000 mg/kg（i.v.）. 在大鼠体内,Gastrodin（5 mg/kg）对环己酰亚胺和阿扑吗啡诱导的健忘症有改善效果,但对莨菪碱诱导的获得性损伤无疗效.故Gastrodin对记忆的巩固和恢复有促进作用,但不能促进记忆的获取. |
| In vivo | 在脂多糖刺激的小胶质细胞中,Gastrodin（30/40/60 mM）可抑制NF-κB信号通路和MAPKs磷酸化作用,从而显著减弱神经毒性的炎症介质和炎症因子的水平。在H9c2心肌细胞中,Gastrodin还可使PI3-K/Akt信号上调,进而抑制NF-κB和MAPKs的激活。 |
| Synonyms | 天麻素, Gastrodine |
| molecular weight | 286.28 |
| Molecular formula | C13H18O7 |
| CAS | 62499-27-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | Ethanol: < 1 mg/mL (insoluble or slightly soluble) DMSO: 55 mg/mL (192.12 mM) H2O: < 1 mg/mL (insoluble or slightly soluble) |
| References | 1. Dai JN, et al. PLoS One, 2011, 6(7), e21891. 2. Yang P, et al. Biochem Pharmacol, 2013, 85(8), 1124-1133. 3. Hsieh MT, et al. J Ethnopharmacol, 1997, 56(1), 45-54. |