| Description | Chebulic acid, a phenolcarboxylic acid compound isolated from Terminalia chebula, has potent anti-oxidant activity,which breaks the cross-links of proteins induced by advanced glycation end-products (AGEs) and inhibits the formation of AGEs.It has effects against the progression of AGE-induced endothelial cell dysfunction,may constitute a promising intervention agent against diabetic vascular complications |
| In vitro | chebulic acid prevents the glycer-AGEs-induced ROS formation of LX-2 cells and collagen accumulation by ERK-phosphorylation-mediated Nrf2 nuclear translocation, which causes upregulation of antioxidant protein production[2]. |
| molecular weight | 356.24 |
| Molecular formula | C14H12O11 |
| CAS | 23725-05-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 260 mg/mL (729.85 mM), Sonication is recommended. |
| References | 1. Effects of chebulic acid on advanced glycation endproducts-induced collagen cross-links.Biol Pharm Bull. 2014;37(7):1162-7. Epub 2014 Apr 24. 2. Koo Y C , Pyo M C , Nam M H , et al. Chebulic acid prevents hepatic fibrosis induced by advanced glycation end-products in LX-2 cell by modulating Nrf2 translocation via ERK pathway.[J]. Toxicology in Vitro, 2016, 34:8-15. |