| Description | Gastrin I, human (Gastrin I (human)) is an endogenous peptide produced in the stomach that increases pepsinogen and acid secretion via the CCK2 receptor in the rat. |
| In vitro | Gastrin I, human, 是一种在胃中产生的内源性肽，通过胆囊收缩素2 (CCK2) 受体发挥作用。[1] |
| In vivo | Gastrin I, human（以1.5、5、15及45 nmol/kg剂量，静脉注射）能增加大鼠的胃蛋白酶原和酸的分泌。[1] |
| Synonyms | Gastrin I (human) |
| molecular weight | 2098.2 |
| Molecular formula | C97H124N20O31S |
| CAS | 10047-33-3 |
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 40 mg/mL (19.06 mM), when pH is adjusted to 11 with NH3·H2O. Sonication is recommended. 1% NH3·H2O: 1 mg/mL, Sonication is recommended. |
| References | 1. Noble F, et al. International Union of Pharmacology. XXI. Structure, distribution, and functions of cholecystokinin receptors. Pharmacol Rev. 1999 Dec;51(4):745-81. 2. Blandizzi C, et al. CCK1 and CCK2 receptors regulate gastric pepsinogen secretion. Eur J Pharmacol. 1999 May 28;373(1):71-84. 3. Sato et al (2015) SnapShot: Growing Organoids from Stem Cells. Cell 161 1700 PMID: 4. Mahe et al (2014) Establishment of gastrointestinal epithelial organoids Curr.Protoc. Mouse Biol. 3 217 PMID: 5. Bartfeld et al (2015) In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection. Gastroenterology 148 126 PMID: |