| Description | Garcinone C is a xanthone derivative extracted from Garcinia oblongifolia Champ with anti-inflammatory, astringency, and granulation-promoting activities. Garcinone C is an AChE inhibitor and has potential cytotoxic effects on certain cancers. |
| In vitro | Garcinone C is active against both of pathogenic (MIC =100 μg/ml) and non-pathogenic leptospira (MIC = 200 μg/ml)[1]. Garcinone C stimulates the expression levels of ATR and 4E-BP1, while efficiently inhibiting the expression levels of cyclin B1, cyclin D1, cyclin E2, cdc2, Stat3, and CDK7. Garcinone C significantly inhibits cell viability of the human nasopharyngeal carcinoma (NPC) cell lines CNE1, CNE2, HK1, and HONE1 in a time‑ and dose‑dependent manner[2]. |
| Synonyms | 伽升沃 C, 伽升沃C |
| molecular weight | 414.45 |
| Molecular formula | C23H26O7 |
| CAS | 76996-27-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Seesom W, et al. Antileptospiral activity of xanthones from Garcinia mangostana and synergy of gamma-mangostin with penicillin G. BMC Complement Altern Med. 2013 Jul 19;13:182. 2. Xia Y, et al. Garcinone C exerts antitumor activity by modulating the expression of ATR/Stat3/4E BP1 in nasopharyngeal carcinoma cells. Oncol Rep. 2018 Mar;39(3):1485-1493. |