| Description | Ercalcitriol (1α,25-Dihydroxy Vitamin D2) is an active metabolite of vitamin D2. Ercalcitriol, as the physiological activated form of vitamin D, can strengthen immunity via regulation of cathelicidin antimicrobial peptide (CAMP) and defensin β-4 (DEFB4) genes in normal and transformed cells to combat pathogenic infections. |
| In vivo | Ercalcitriol与维生素D受体(VDR)（一种核受体）结合，激活VDR和视黄酸X受体(RXR)之间的相互作用形成VDR/RXR/辅因子复合体，该复合体与目标基因启动子区域的维生素D响应元素结合，以调控基因转录[3]。 |
| Synonyms | 1α,25-Dihydroxy Vitamin D2 |
| molecular weight | 428.65 |
| Molecular formula | C28H44O3 |
| CAS | 60133-18-8 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 45.0 mg/mL (105.0 mM) |
| References | 1. Mawer EB, Berry JL, Cundall JP, Still PE, White A.A sensitive radioimmunoassay using a monoclonal antibody that is equipotent for ercalcitriol and calcitriol (1,25-dihydroxy vitamin D2 and D3).Clin Chim Acta. 1990 Oct 15;190(3):199-209. 2. Shamik J. Parikh, Marni Edelman, Gabriel I. Uwaifo et al. The Relationship between Obesity and Serum 1,25-Dihydroxy Vitamin D Concentrations in Healthy Adults. The Journal of Clinical Endocrinology & Metabolism March 1, 2004 vol. 89 no. 3 1196-1199 3. Nakane M, et al. Differential effects of Vitamin D analogs on bone formation and resorption. J Steroid Biochem Mol Biol. 2006 Jan;98(1):72-7. 4. Gombart AF, et al. Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D3. FASEB J. 2005 Jul;19(9):1067-77. |