| Description | Andrograpanin (19-HYDROXY-8(17),13-LABDADIEN-16,15-OLIDE) is a bioactive compound from Andrographis paniculata. Andrograpanin has anti-inflammatory and anti-infectious properties. |
| In vitro | Andrograpanin enhances chemokine SDF-1α-induced leukocytes chemotaxis in Jurkat, THP-1 and PBL cells[1]. Andrograpanin exhibits anti-inflammatory properties through down-regulating the p38 MAPKs signaling pathways in lipopolysaccharide-induced macrophage cells[2]. |
| Synonyms | 19-HYDROXY-8(17),13-LABDADIEN-16,15-OLIDE, 新穿心莲内酯苷元 |
| molecular weight | 318.45 |
| Molecular formula | C20H30O3 |
| CAS | 82209-74-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 55 mg/ml (172.71 mM) |
| References | 1. Liu J , Wang Z T , Ge B X . Andrograpanin, isolated from Andrographis paniculata, exhibits anti-inflammatory property in lipopolysaccharide-induced macrophage cells through down-regulating the p38 MAPKs signaling pathways[J]. International Immunopharmacology, 2008, 8(7):951-958. 2. Andrograpanin, a compound isolated from anti‐inflammatory traditional Chinese medicine Andrographis paniculata, enhances chemokine SDF‐1α‐induced leukocytes chemotaxis[J]. Journal of Cellular Biochemistry, 2005, 95(5). |