| Description | (-)-Epicatechin gallate ((-)-Epicatechin 3-O-gallate) is one of the catechin isomers and a potent antioxidant that can modulate a wide range of membrane proteins. Its bilayer-modifying potency was tested using gramicidin A (gA) channels as probes. All the catechins alter gA channel function and modify bilayer properties, with a 500-fold range in potency. The gallate group causes current block, as evident by brief downward current transitions. |
| Target activity | COX-1:7.5 μM. |
| Synonyms | 表儿茶素没食子酸酯, (−)-Epicatechin 3-gallate, Epicatechin gallate, (-)-Epicatechin 3-gallate, (-)-Epicatechin 3-O-gallate, ECG |
| molecular weight | 442.37 |
| Molecular formula | C22H18O10 |
| CAS | 1257-08-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 55 mg/mL (124.33 mM) H2O: 2.5 mg/mL (5.65 mM), Sonication is recommended. |
| References | 1. Rosado H, et al. Int J Mol Sci. 2015 Jul 23;16(8):16710-27. 2. Hwang Y H, Jang S A, Kim T, et al. Anti-osteoporotic and Anti-adipogenic Effects of Rhus chinensis Nutgalls in Ovariectomized Mice Fed with a High-fat Diet[J]. Planta medica. 2019. |