| Description | Dihydrosanguinarine is a natural compound isolated from the leaves of Macleaya microcarpa,and has antifungal and anticancer activity. |
| In vitro | Dihydro Sanguinarine may cause both necrosis and apoptosis of HL-60 cells[1]. |
| In vivo | Dihydrosanguinarine was?effective against I. multifiliis with median effective concentration (EC(50)) values of 5.18mg/l.?The acute toxicities (LC(50)) of dihydrosanguinarine and dihydrochelerythrine for richadsin was 13.3mg/l,?The overall results provided important information for the potential application of dihydrosanguinarine and dihydrochelerythrine in the therapy of serious infection caused by I. multifiliis[2]. |
| Synonyms | 13,14-Dihydrosanguinarine, Dihydro Sanguinarine, 二氢血根碱 |
| molecular weight | 333.34 |
| Molecular formula | C20H15NO4 |
| CAS | 3606-45-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 5.2 mg/mL (15.60 mM) |
| References | 1. Vrba J,Dolezel P, Vicar J,et,al.Cytotoxic activity of sanguinarine and dihydrosanguinarine in human promyelocytic leukemia HL-60 cells[J].Toxicol In Vitro. 2009 Jun;23(4):580-8 2. Yao J Y , Zhou Z M , Li X L , et al. Antiparasitic efficacy of dihydrosanguinarine and dihydrochelerythrine from Macleaya microcarpa against Ichthyophthirius multifiliis in richadsin (Squaliobarbus curriculus)[J]. Veterinary Parasitology, 2011, 183(1-2):8-13. |