| Description | Deoxylapachol has anti-wood rot activity, it can inhibit the brown rot fungi Gloeophyllum sepiarium CBS 353.74 and Gloeophyllum trabeum CBS 318.50 and the white rot fungi Merulius tremellosus CBS 280.73 and Phlebia brevispora CBS 509.92. It also can induce fungal cell wall stress. |
| In vitro | Teak ( Tectona grandis L.f., Verbenaceae) sawdust extract inhibited the growth of Aspergillus niger. By (1)H-NMR the active compounds were identified as Deoxylapachol and tectoquinone. Two A. niger transgenic strains which show induction of 1,3 -alpha-D-glucan synthase were used as a cell wall damage model[1]. Deoxylapachol is active against P-388 leukemia cells with IC50 of 0.6 microgm/ml). |
| Target activity | P388 leukemia cells:0.6 microgm/ml |
| molecular weight | 226.27 |
| Molecular formula | C15H14O2 |
| CAS | 3568-90-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 95 mg/mL (419.85 mM) |
| References | 1. Activity of quinones from teak (Tectona grandis) on fungal cell wall stress.Planta Med. 2006 Aug;72(10):943-4. 2. N B Perry, et al. A cytotoxic and antifungal 1,4-naphthoquinone and related compounds from a New Zealand brown algae, Landsburgia quercifolia. J Nat Prod. Jul-Aug 1991;54(4):978-85. |