| Description | Dehydroevodiamine (DHE), a natural compound isolated from Evodia rutaecarpa, can inhibit AChE. It has hypotensive and neuroprotective effects and modulates nitric oxide production. |
| In vivo | Dehydroevodiaminehydrochloride has strong protective effects against cognitive impairments through its antioxidant activity and inhibition of neurotoxicity and intracellular calcium. Thus, DHED may be an important therapeutic agent for memory-impaired symptoms. |
| Animal experiments | The effects of dehydroevodiamine·HCl (DHED) on cognitive improvement and the related mechanism in memory-impaired rat models, namely, a scopolamine-induced amnesia model and a Aβ1-42-infused model. The cognitive effects of DHED were measured using a water maze test and a passive avoidance test in the memory-impaired rat models. The results demonstrate that DHED (10 mg/kg, p.o.) and Donepezil (1 mg/kg, p.o.) ameliorated the spatial memory impairment in the scopolamine-induced amnestic rats. |
| molecular weight | 337.8 |
| Molecular formula | C19H16ClN3O |
| CAS | 111664-82-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 37 mg/mL (109.53 mM) |
| References | 1. Shin K Y , Kim K Y , Suh Y H . Dehydroevodiamine·HCl enhances cognitive function in memory-impaired rat models[J]. Korean Journal of Physiology and Pharmacology, 2017, 21(1). |
Dehydroevodiamine hydrochloride
CAS No.: 111664-82-5
Dehydroevodiamine (DHE), a natural compound isolated from Evodia rutaecarpa, can inhibit AChE. It has hypotensive and ne
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