| Description | Damnacanthal possesses anti-cancer, immunomodulatory, antinociceptive and anti-inflammatory actions, it can treat or prevent hepatocellular carcinoma through its inhibitory effects on the HGF/c-Met axis. |
| In vitro | Here we show that Damnacanthal has profound inhibitory activity on mast cell activation through this pathway. The release of the granule compounds beta-hexosaminidase and tryptase release was completely abrogated by Damnacanthal at doses that were non-toxic to mast cells. In addition, Damnacanthal inhibited activation-dependent pro-inflammatory gene induction, as well as cytokine/chemokine release in response to mast cell stimulation. The mechanism underlying Damnacanthal inhibition was linked to impaired phosphorylation of Syk and Akt. Furthermore, Damnacanthal inhibited mast cell activation in response to calcium ionophore A23187[1] |
| Target activity | p56lck autophosphorylation:46 nM (IC50), Phosphorylation of exogenous substrates by p56lck:220 nM (IC50) |
| Synonyms | 丹宁卡 |
| molecular weight | 282.25 |
| Molecular formula | C16H10O5 |
| CAS | 477-84-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Damnacanthal inhibits IgE receptor-mediated activation of mast cells.Mol Immunol. 2015 May;65(1):86-93. |