| Description | Crustecdysone (Hydroxyecdysone) is a steroid hormone that regulates the processes of molting or ecdysis in insects. |
| In vitro | 在高脂肪饮食的C57BL / 6J小鼠中,口服20-Hydroxyecdysone（10 mg / kg /天,13周）能够改善肥胖和胰岛素水平,降低体重和体脂含量. |
| In vivo | 在CoCl2诱导的细胞中,20-Hydroxyecdysone降低活性氧（ROS）产生,减少线粒体膜的去极化,抑制细胞色素c释放入细胞质,从而改善细胞损伤。在H4IIE细胞中,20-Hydroxyecdysone能够降低磷酸烯醇式丙酮酸羧激酶（PEPCK）和葡萄糖-6-磷酸酶（G6Pase）的表达,降低葡萄糖产量。 |
| Synonyms | Commisterone, B-ecdysone,Commisterone, 20-Hydroxyecdysone, Ecdysterone, B-ecdysone, β-蜕皮甾酮, Hydroxyecdysone, 羟基蜕皮激素 |
| molecular weight | 480.63 |
| Molecular formula | C27H44O7 |
| CAS | 5289-74-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 55 mg/mL (114.43 mM) H2O: < 1 mg/mL (insoluble or slightly soluble) Ethanol: 89 mg/mL (185.2 mM) |
| References | 1. Kizelsztein P, et al. Am J Physiol Endocrinol Metab, 2009, 296(3), E433-439. 2. Hu J, et al. J Cell Biochem, 2010, 111(6), 1512-1521. 3. Peschel W, et al. J Pharm Pharmacol, 2011, 63(11), 1483-1495. 4. Tian L, et al. Arch Insect Biochem Physiol, 2012, 79(4-5), 207-219. 5. Hung TJ, et al. J Diabetes Complications, 2012. 6. Phungphong S, et al. 20-Hydroxyecdysone attenuates cardiac remodeling in spontaneously hypertensive rats. Steroids. 2017 Oct;126:79-84. |