| Description | Conessine (Conessinum), a steroidal alkaloid isolated from Holarrhena floribunda, interacts with the histamine H3 receptor and has anti-malarial activity. |
| Target activity | H3 receptor (guinea pig brain):6.0 nM (Ki), H3 receptor:5.4 nM (Ki), H3 receptor (dog):5.7 nM (Ki), H3 receptor (rat):25 nM (Ki) |
| Synonyms | Conessinum, Wrightine, 地麻素, Roquessine, Neriine, Konessin |
| molecular weight | 356.59 |
| Molecular formula | C24H40N2 |
| CAS | 546-06-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: < 3 mg/mL Ethanol: 30 mg/mL (84.13 mM), Sonication is recommended. |
| References | 1. Kim H, Lee KI, Jang M, Namkoong S, Park R, Ju H, Choi I, Oh WK, Park J. Conessine Interferes with Oxidative Stress-Induced C2C12 Myoblast Cell Death through Inhibition of Autophagic Flux. PLoS One. 2016 Jun 3;11(6):e0157096. doi: 10.1371/journal.pone.0157096. eCollection 2016. PubMed PMID: 27257813; PubMed Central PMCID: PMC4892631. 2. Morais-Silva G, Ferreira-Santos M, Marin MT. Conessine, an H3 receptor antagonist, alters behavioral and neurochemical effects of ethanol in mice. Behav Brain Res. 2016 May 15;305:100-7. doi: 10.1016/j.bbr.2016.02.025. Epub 2016 Feb 26. PubMed PMID: 26924015. 3. Siriyong T, Chusri S, Srimanote P, Tipmanee V, Voravuthikunchai SP. Holarrhena antidysenterica Extract and Its Steroidal Alkaloid, Conessine, as Resistance-Modifying Agents Against Extensively Drug-Resistant Acinetobacter baumannii. Microb Drug Resist. 2016 Jun;22(4):273-82. doi: 10.1089/mdr.2015.0194. Epub 2016 Jan 8. PubMed PMID: 26745443. 4. Dua VK, Verma G, Singh B, Rajan A, Bagai U, Agarwal DD, Gupta NC, Kumar S, Rastogi A. Anti-malarial property of steroidal alkaloid conessine isolated from the bark of Holarrhena antidysenterica. Malar J. 2013 Jun 10;12:194. doi: 10.1186/1475-2875-12-194. PubMed PMID: 23758861; PubMed Central PMCID: PMC3685520. |