| Description | Chebulagic acid, isolated from the Terminalia chebula Retz, is a COX-LOX dual inhibitor. |
| In vitro | Chebulagic acid可以增强自噬作用，并具有抗炎和抗感染的效果[1,2]。此外，Chebulagic acid 对1-甲基-4-苯基吡啶（MPP+）引起的细胞毒性显示出保护作用，该细胞毒性模拟帕金森病的病理症状。Chebulagic acid还能在剂量和时间依赖的方式中抑制LPS诱导的TNF-α和IL-1β的上调[3]。 |
| molecular weight | 954.66 |
| Molecular formula | C41H30O27 |
| CAS | 23094-71-5 |
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 98 mg/mL (102.66 mM), Sonication is recommended. |
| References | 1. Kim HJ et al. Neuroprotective Effect of Chebulagic Acid via Autophagy Induction in SH-SY5Y Cells. Biomol Ther (Seoul). 2014 Jul;22(4):275-81. 2. Liu Y et al. Chebulagic acid inhibits the LPS-induced expression of TNF-α and IL-1β in endothelial cells by suppressing MAPK activation. Exp Ther Med. 2015 Jul;10(1):263-268. 3. Athira AP et al. Inhibition of Angiogenesis In Vitro by Chebulagic Acid: A COX-LOX Dual Inhibitor. Int J Vasc Med. 2013;2013:843897. |