| Description | Brassinin (BSN) (BSN) is a phytoalexin isolated from B. campestris that exhibits anticancer, chemopreventative, antiproliferative, and antifungal activities. |
| In vitro | In lung cancer cells, brassinin inhibits constitutive and IL-6-inducible STAT3 signaling through modulation of PIAS-3 and SOCS-3.It appears that brassinin induces apoptosis in PC-3 prostate cancer cells via the suppression of PI3K/Akt/mTOR/S6K1 signaling. |
| In vivo | Brassinin attenuates tumor growth in a xenograft lung cancer mouse model through modulation of E3 SUMO-protein ligase 3 (PIAS-3) and suppressor of cytokine signaling-3 (SOCS-3). |
| Synonyms | BSN, 芸苔宁 |
| molecular weight | 236.36 |
| Molecular formula | C11H12N2S2 |
| CAS | 105748-59-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 55 mg/mL (232.71 mM) |
| References | 1. Kim SM,etal.Brassinin induces apoptosis in PC-3 human prostate cancer cells through the suppression of PI3K/Akt/mTOR/S6K1 signaling cascades.Phytother Res. 2014 Mar;28(3):423-31. 2. Pedras MS,etal.Phytoalexins from the crucifer rutabaga: structures, syntheses, biosyntheses, and antifungal activity.J Org Chem. 2004 Jun 25;69(13):4471-6. 3. Lee JH,et al.Brassinin inhibits STAT3 signaling pathway through modulation of PIAS-3 and SOCS-3 expression and sensitizes human lung cancer xenograft in nude mice to paclitaxel.Oncotarget. 2015 Mar 20;6(8):6386-405. |