| Description | ATP disodium trihydrate (Adenosine-5'-triphosphate disodium trihydrate) is an important substance for energy storage and metabolism in the body. It is an important endogenous signaling molecule in immunity and inflammation, which provides energy for the body's metabolism and also acts as a coenzyme in cells. |
| In vitro | ATP disodium trihydrate (5 mM; 1 h) with LPS (1 μg/mL) has a synergistic effect on the activation of the NLRP3 inflammasome in HGFs.[3]ATP disodium trihydrate (2 mM; 0.5-24 h) induces BMDM to secrete IL-1β, KC and MIP-2 in a caspase-1 activation-dependent manner.[4]ATP disodium trihydrate promotes neutrophil chemotaxis.[4] |
| In vivo | ATP disodium trihydrate (50 mg/kg; ip) protects mice against bacterial infection.[4]ATP disodium trihydrate induces the secretion of IL-1β, KC and MIP-2, neutrophil recruitment.[4] |
| Synonyms | Adenosine-5'-triphosphate disodium trihydrate |
| molecular weight | 607.21 |
| Molecular formula | C10H22N5Na2O16P3 |
| CAS | 51963-61-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 0.9 mg/mL (1.5 mM), Sonication and heating to 80℃ are recommended. H2O: 225.0 mg/mL (371.8 mM), Sonication is recommended. |
| References | 1. Swennen EL, et al. Immunoregulatory effects of adenosine 5'-triphosphate on cytokine release from stimulated whole blood. Eur J Immunol. 2005;35(3):852-858. 2. Bours MJ, et al. Adenosine 5'-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation. Pharmacol Ther. 2006;112(2):358-404. 3. Xu S, et al. Doxycycline inhibits NAcht Leucine-rich repeat Protein 3 inflammasome activation and interleukin-1β production induced by Porphyromonas gingivalis-lipopolysaccharide and adenosine triphosphate in human gingival fibroblasts. Arch Oral Biol. 2019;107:104514. 4. Xiang Y, et al. Adenosine-5'-triphosphate (ATP) protects mice against bacterial infection by activation of the NLRP3 inflammasome. PLoS One. 2013;8(5):e63759. |