| Description | Asperphenamate is a fungal metabolite of Aspergillus flatiipes. The IC50s for T47D cells, MDA-MB-231 cells, and HL-60 cells are 92.3 μM, 96.5 μM, and 97.9 μM. Asperphenamate shows an anticancer effect. |
| In vitro | Asperphenamate 诱导自噬并抑制癌细胞增殖。Asperphenamate 抑制蛋白酶 cathepsin L，并且对蛋白酶 cathepsin S 也有弱抑制作用[1]。 |
| molecular weight | 506.59 |
| Molecular formula | C32H30N2O4 |
| CAS | 63631-36-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 90.0 mg/mL (177.7 mM), Sonication is recommended. |
| References | 1. Alice M.Clark, et al. Synthesis of asperphenamate, a novel fungal metabolite. Phytochemistry 2. LeiYuan, et al. Total synthesis and anticancer activity studies of the stereoisomers of asperphenamate and patriscabratine. Chinese Chemical Letters Volume 21, Issue 2, February 2010, Pages 155-158. 3. Yuan L, et al. Discovery of novel cathepsin inhibitors with potent anti-metastatic effects in breast cancer cells. Bioorg Chem. 2018 Dec;81:672-680. |