| Description | Deoxypodophyllotoxin shows cytotoxic , antineoplastic, antitumor, insecticidal, anti-angiogenic, vascular disrupting, insecticidal, antiviral, and anti-inflammatory activities. |
| In vitro | Deoxypodophyllotoxin (DPT) induced both apoptosis and autophagy via production of mitochondrial reactive oxygen species (ROS).?DPT suppressed the PI3K/AKT/mTOR signaling cascades to lead autophagy process, resulting from conversion of light chain 3-I (LC3-I) into LC3-II and acidic vesicular organelles (AVOs) formation.?Even if DPT-induced ROS were occurred in both apoptosis and autophagy, inhibition of ROS generation enhanced cell viability.?Otherwise, 3-methyladeine (3-MA) impeding on autophagy accelerated an apoptotic response caused by DPT.?Therefore, these findings suggest that DPT triggers cytoprotective autophagy against cytotoxic apoptosis[1]. |
| Synonyms | 脱氧鬼臼毒素, 去氧鬼臼毒素 |
| molecular weight | 398.41 |
| Molecular formula | C22H22O7 |
| CAS | 19186-35-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 55 mg/mL (138.05 mM) |
| References | 1. Kim SH, et al. Deoxypodophyllotoxin induces cytoprotective autophagy against apoptosis via inhibition of PI3K/AKT/mTOR pathway in osteosarcoma U2OS cells. Pharmacol Rep. 2017 Oct;69(5):878-884. 2. Deoxypodophyllotoxin exerts both anti-angiogenic and vascular disrupting effects.Int J Biochem Cell Biol. 2013 Aug;45(8):1710-9. |